Genetic factors in drug therapy clinical and molecular pharmacogenetics by David A. Price Evans

Cover of: Genetic factors in drug therapy | David A. Price Evans

Published by Cambridge University Press in Cambridge [England], New York .

Written in English

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  • Pharmacogenetics.,
  • Pharmacogenetics.,
  • Drug Therapy.,
  • Genetics, Medical.,
  • Variation (Genetics) -- drug effects.

Edition Notes

Includes bibliographical references (p. 627) and index.

Book details

StatementDavid A. Price Evans.
LC ClassificationsRM301.3.G45 P75 1993
The Physical Object
Paginationxxiii, 657 p. :
Number of Pages657
ID Numbers
Open LibraryOL1408480M
ISBN 10052141296X
LC Control Number93017041

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Genetic Factors in Drug Therapy is the first comprehensive, in-depth survey of the current research on the genetic basis for the wide variety in people's responses to drugs. Evans shows how understanding inherited differences in the rates at which people metabolize drugs and in their response to drugs in general leads to a clearer Cited by: Genetic factors in drug therapy: clinical and molecular pharmacogenetics.

[David A Price Evans] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for exhaustively and lucidly covered in this monumental book.

Gene therapy is likely to have an enormous impact on medicine in the future. Many diseases are known to have a genetic component, whether the result of a specific gene defect or the combination of complex genetic factors. The concept of using DNA as a drug is now a reality, and healthcare professionals need to appreciate this by:   For assistance, please contact: AAN Members () or () (International) Non-AAN Member subscribers () or () option 3, select 1 Author: Fccp P.

PharmD, K. Oles, PharmD, Bcps. The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response.

These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments.

This book presents Pharmacogenetic examples Cited by: Pharmacogenomics (also known as pharmacogenetics) is the area of medicine that addresses the impact of genetic factors on drug actions.

For therapeutic drugs, the goal of pharmacogenomics is to optimize drug efficacy while minimizing or avoiding toxic effects. In principle, genetic variation can influence pharmacodynamics, pharmacokinetics, or. Finding the Golden Genes: Advances in Gene Therapy Could Tempt Some Athletes to Enhance Their Genetic Makeup, Leading Some Researchers to Work on Detection Methods Just in Case By Barry, Patrick Science News, Vol.

No. 3, August 2, One definition, is that it is medical practice with the knowledge and expertise to optimize drug therapy in the face of the many factors that combine to determine individual patient variability in drug response: patient factors; for example genetics, age, genetics, gender, concurrent disease, concurrent drug therapy and environmental agents.

The aim of pharmacogenomics is to enable the prescribing of drug therapy to be genetically guided, thereby optimising its effectiveness and reducing adverse side effects. The recognition that most human drug responses are multifactorial has led to the realisation that personalised or individualised medicine implies a broad consideration of factors and thus has resulted in the.

This is a set of powerpoint slides with self-assessment questions interspersed throughout on drug metabolism and pharmacogenetics. The aim is to understand the mechanism of clinically significant drug interactions, recognize potentially clinically significant genetic influences on drug efficacy and toxicity, and genetic predispositions to disease due to altered drug metabolism or transport.

Of these factors, age and genetic influences have been pinpointed as significant contributors to problems with drug therapy. Keywords Adverse Drug Reaction Malignant Hyperthermia G6PD Deficiency Malignant Hyperpyrexia Dibucaine Number.

Drug Safety—Using Genetic Screening to Identify Risk Factors for Adverse Events. Mechanisms are primarily through HLA and ADME genes.

Most HLA genetic risk factors are drug- and serious adverse event-specific (i.e., one cannot extrapolate across drugs or across adverse events for a drug). Clinical pharmacogenetics, the use of genetic data to guide drug therapy decisions, is beginning to be used for medications commonly prescribed by family physicians.

However, clinicians are. Drugs of abuse, including opioids, act on the brain’s reward system, a system that transfers signals primarily via a molecule (neurotransmitter) called dopamine. The function of this system is affected by genetic and environmental factors.

For example, a recent study published in the scientific journal PNAS revealed one of those genetic. Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement.

It also provides assistance in designing procedures and pharmacological approaches to further the use. GENETIC FACTORS IN DRUG THERAPY Clinical and molecular pharmacogenetics David A. Price Evans, MD, DSc, PhD, FRCP Director of Medicine, Riyadh Armed Forces Hospital, Saudi Arabia CAMBRIDGE UNIVERSITY PRESS.

CONTENTS Preface page xxiii ^Part I Introduction 1 The arrangement of the information in this volume 1. a specific gene [but we should be able to consider that genes are a part of the family history] The gene allows us to identify people at risk -- no one of who can be pointed to and say they will develop a disorder -- there is a heterogeneity regarding phenotypes and specific genes.

Conducting Genetic Research. Addiction is a multifaceted condition. It is caused by environmental influences as well as genetic factors. Both risk factors and protective factors are associated with drug dependence. Risk factors increase the chance that someone will develop an addiction, while protective factors decrease the chance.

Common risk factors include: 9,   Polycythaemia vera is a chronic malignant disease of the haematopoietic system and is treated with interferon-alpha-based drugs, in most cases.

The Genomics and Targeted Therapy Group is located within FDA’s Office of Clinical Pharmacology and works to apply pharmacogenomics and other biomarkers in drug development and clinical practice.

Most treatment strategies for genetic disorders do not alter the underlying genetic mutation; however, a few disorders have been treated with gene therapy.

This experimental technique involves changing a person's genes to prevent or treat a disease. The NIH’s National Institute on Drug Abuse has awarded Price Dickson, Ph.D., a five-year Pathway to Independence Award (K99/R00) to discover the genetic underpinnings that make individuals susceptible or resistant to addiction in the face of chronic stress.

Encyclopedia of Drug Metabolism and Interactions discusses all pre-clinical, clinical, toxicological, regulatory and marketing perspectives of drug metabolism and interactions.

This state-of-the-art reference covers the various types of enzymes that can be inhibited or induced and their impact on drug toxicity and altered response for both animal models and humans. A review paper published by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) indicates that genetic factors may contribute to as much as 50 to 60 percent of the variance in risk for developing alcohol dependence; while this percentage underscores the significance of genetic influences, it also suggests that several nongenetic.

The premier text on substance abuse and addictive behaviors is now in its updated and expanded Fourth Edition, with up-to-the-minute insights from more than experts at the front lines of patient management and research. This edition features expanded coverage of the neurobiology of abused substances, new pharmacologic therapies for addictions, and complete information on “club drugs 4/5(3).

Nineteen identical (monozygotic) and 20 fraternal (dizygotic) sets of twins between 45 and 51 years of age were given nortriptyline orally in doses of 02 mg./kg. body weight three times daily for eight days.

The steady-state plasma concentrations of nortriptyline were calculated from the mean of the determinations for days 6, 7, and 8. Identical twins, not treated with other drugs, achieved.

Accordingly, many of the genetic factors affecting risk for dependence on alcohol or other drugs appear to act through a general externalizing factor; however, other genetic factors appear to be specific to a certain disorder. In recent years, researchers have identified numerous genes as affecting risk for dependence on alcohol and other drugs.

Keywords: mental disorders, genetics; neurosciences; mental disorders, drug therapy; genetic predisposition to disease; antipsychotic agents, therapeutic use.

Voir page le re´sume´ en franc¸ais. Pharmacogenomics (PGx) is useful in elucidating factors causing individual differences in drug efficacy and the emergence of adverse effects.

It also helps design accurate drug administration methods by evaluating the effects of patient-related factors, such as genetic factors, that influence pharmacokinetics (PK) and pharmacodynamics (PD). MedlinePlus Genetics provides information about the effects of genetic variation on human health.

Learn about genetic conditions, genes, chromosomes, and more. Exposure to other drugs also influences the steady-state plasma concentration of nortriptyline, which in a given patient may therefore be determined by a resultant of genetic and environmental factors.

Background: Arthralgia is a common and debilitating toxicity of aromatase inhibitors (AI) that leads to premature drug discontinuation. We sought to evaluate the clinical and genetic risk factors associated with AI-associated arthralgia (AIAA).

Methods: We performed a cross-sectional study among postmenopausal women with stage 0-III breast cancer who were prescribed a third-generation AI for. "The results of this research once again direct us towards personalized cancer therapy," says Prof. Alimonti. "Genetic factors of the patient can in fact determine whether senescence has a.

Finding the suspect genes and their variants linked to addiction has been helped by large databases now being shared by scientists. This NIDA-funded study broke new ground by checking recorded data of up to million people, simultaneously looking at multiple substance use behaviors and then cross-checking them to potential genetic factors.

Pharmacogenetics has elucidated the genetic basis for interindividual variability in drug response and will continue to play a key role in defining strategies to optimize drug therapy. Introduction. This publication, also available in Spanish, provides estimated numbers of new cancer cases and deaths for Hispanics/Latinos, as well as the most recent statistics on cancer occurrence and information on cancer risk factors (e.g., tobacco use, obesity, and alcohol consumption) and.

Venous thromboembolism (VTE) is a multifactorial disease driven by environmental/acquired risk factors such as age, obesity, oral contraceptives, and immobility, as well as inherited risk factors such as genetic polymorphisms.

[1, 2, 3] VTE causes formation of blood clots, primarily of the deep the United States, it affectstoindividuals each year. Treatments that specifically target HER2 are very effective.

These treatments are so effective that the prognosis for HER2-positive breast cancer is actually quite good. Certain standard chemotherapy drugs also can be effective in treating HER2-positive breast cancers, although these drugs don't specifically target the HER2 protein.

Experts recommend that every invasive breast cancer be. Alcoholism, more appropriately referred to as alcohol use disorder (AUD), is, broadly, any drinking of alcohol that results in mental and/or physical health problems ranging anywhere from mild and imperceptible without special testing to severe and grossly overt.

The disorder was previously divided into two types: alcohol abuse and alcohol dependence. In a medical context, alcoholism is said. Aug. 26, — More frequent seizures during the menstrual cycle in women with genetic generalized epilepsy have been linked for the first time to drug-resistant epilepsy, when anti-seizure.

Genetic Factors in Addiction and Alcoholism Alcoholism and drug addiction start out as behaviors that are influenced by both genetic and environmental factors. A person who is raised in an environment where alcohol and drugs are omnipresent is more likely to have a drink or to use drugs than a person who has no such exposure to those substances.Screening for Cytochrome P Screening for cytochrome P shouldn’t routinely be done for 2 reasons: 1) The tests are extremely expensive, and 2) There are 3 different CYP defects that significantly alter opioid metabolism.

1 Unfortunately, only 2 of the 3 defects have a commercially available test (CYP2D6 and CYP2C9).The most common CYP defect, however, is believed to be .Male infertility refers to a male's inability to cause pregnancy in a fertile female.

In humans it accounts for 40–50% of infertility. It affects approximately 7% of all men. Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity.

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